Web18 Nov 2012 · Br J Dermatol 1992; 126 Suppl. 39: 14–8. Article PubMed Google Scholar. Yun C, Okerholm RA, Guengerich FP. Oxidation of the antihistaminic drug terfenadine in human liver microsomes: role of cytochrome P-450 3A (4) in N-dealkylation and C-hydroxylation. Drug Metab Dispos 1993; 21: 403–9. PubMed CAS Google Scholar. Web31 Dec 1998 · Abstract: Terfenadine is a nonsedating H1-antagonist that when overdosed, used with hepatic compromise, or when given with ketoconazole results in accumulation of parent terfenadine, prolongation of the QT interval, and torsades de pointes in susceptible patients. Nine subjects were given the recommended dose of terfenadine (60 mg every 12 …
The effect of ketoconazole on the in vivo intestinal
Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst Marion Roussel (now Sanofi) and was marketed under various brand names, including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia. It was … See more Terfenadine acts as a peripherally-selective antihistamine, or antagonist of the histamine H1 receptor. It is a prodrug, generally completely metabolized to the active form fexofenadine in the liver by the enzyme See more Terfenadine was synthesized by chemists at Richardson–Merrell in 1973 as a potential tranquilizer. However, it was found to be inactive … See more WebThe findings suggest that intraconazole in therapeutic doses inhibits terfenadine metabolism. It is also possible that unmetabolised terfenadine alone, without an increased level of its active metabolite, may cause torsades de pointes. The concomitant use of terfenadine and itraconazole (and ketoconazole) should be avoided. rigins of family namr rhea
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Web30 Dec 2010 · Terfenadine and ketoconazole are the most widely used positive reference agents in non-clinical cardiac repolarization safety studies. The aim of the present study … WebTerjemahan frasa EVIDENCE OF INTERACTION dari bahasa inggris ke bahasa indonesia dan contoh penggunaan "EVIDENCE OF INTERACTION" dalam kalimat dengan terjemahannya: There is no evidence of interaction between the two nations prior... Web14 Apr 2024 · Sertraline does not act as an inhibitor of CYP 3A4, CYP 2C9, CYP 2C19, and CYP 1A2 to a clinically significant degree. This has been confirmed by in-vivo interaction studies with CYP3A4 substrates (endogenous cortisol, carbamazepine, terfenadine, alprazolam), CYP2C19 substrate diazepam, and CYP2C9 substrates tolbutamide, … rigips lichtband