WebWe identified a bHLH transcription factor, Tcf21, that is highly expressed in developing and mature podocytes. Because conventional Tcf21 knockout mice die in the perinatal period with major cardiopulmonary defects, we generated a conditional Tcf21 knockout mouse to explore the role of this transcription factor in podocytes in vivo. Tcf21 was ... WebNov 20, 2024 · Furthermore, Blimp-1 directly inhibited the transcriptional activity of NF-κB and the transcription of IL6 gene. Conclusion Blimp-1 represses the production of multiple pro-inflammatory cytokines by directly binding the genomic region and restricting the nuclear translocation and transcriptional activity of NF-κB.
MAGIC: A tool for predicting transcription factors and cofactors
WebFeb 28, 2010 · Results of an in silico analysis of the P2 sequence further support the assignment of P2 as a bona fide promoter by the localization of putative -10 and -35 … http://www.globalauthorid.com/WebPortal/ArticleView?wd=03E459076164F53E04F51857589A86C1EBE3FD40020C93F21ED448AC0ADE6703 freight midpoint
7.5B: The Promoter and the Transcription Machinery
WebAlgorithm predicts potential transcription start positions of bacterial genes regulated by sigma70 promoters (major E.coli promoter class). ... After that we present elements of … WebIntroduction Transcription factors (TFs) directly interpret the genome, performing the first step in decoding the DNA sequence. Many function as “master regulators” and “selector genes”, exerting control over processes that specify cell types and developmental patterning ( Lee and Young, 2013 WebTFEB is a master gene for lysosomal biogenesis. [7] It encodes a transcription factor that coordinates expression of lysosomal hydrolases, membrane proteins and genes involved in autophagy. [7] [8] Upon nutrient depletion and under aberrant lysosomal storage conditions such as in lysosomal storage diseases, TFEB translocates from the cytoplasm ... freight micro font