Dichloromethylene diphosphonate
WebDepletion of AM by liposome-encapsulated dichloromethylene diphosphonate is shown to cause severalfold enhancement in systemic absorption of IgG and human chorionic gonadotropin after intratracheal instillation in rats. Lowering the doses of IgG delivered to the lungs alleviates local degradation and results in a dramatic increase in systemic ... WebLiposomes containing the drug dichloromethylene diphosphonate (Cl2MDP) can eliminate phagocytic cells, such as macrophages, when injected in vivo. In this paper we report that Cl2MDP-containing liposomes have been used experimentally to determine the extent to which cutaneous macrophages participate …
Dichloromethylene diphosphonate
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WebIt is shown ultrastructurally that intravenously injected and liposome-entrapped dichloromethylene diphosphonate (DMDP) causes marked damage to marginal zone macrophages in the mouse spleen which finally results in the elimination of these cells. Marginal zone lympohocytes are also affected by this treatment, probably as a result of … WebIt is shown ultrastructurally that intravenously injected and liposome-entrapped dichloromethylene diphosphonate (DMDP) causes marked damage to marginal zone macrophages in the mouse spleen which finally results in the elimination of these cells.
WebAbstract Systemic treatment with disodium ethane-hydroxy-1, 1-diphosphonate is ineffective in inhibiting the calcergenic reactions induced in mouse skin by the lanthanides. In contrast, disodium di... WebIt is shown ultrastructurally that intravenously injected and liposome-entrapped dichloromethylene diphosphonate (DMDP) causes marked damage to marginal zone …
WebSystemic treatment with disodium ethane-hydroxy-1, 1-diphosphonate is ineffective in inhibiting the calcergenic reactions induced in mouse skin by the lanthanides. In contrast, disodium dichloromethylene diphosphonate prevents lanthanide calcergy induced by 12 of the 15 compounds tested but only when treatment with Cl 2 MDP is given prior to ... WebDaily administration of dichloromethylene diphosphonate (Cl2MDP) to (C57BL/6 X DBA/2) F1 hybrid mice, from two days of age (10 mg of P/kg body weight), resulted in a …
WebMacrophages lining the subcapsular sinus (SCS) and those located in the medulla of popliteal lymph nodes (PLN) of mice were eliminated after subcutaneous (s.c.) injection of dichloromethylene diphosphonate (Cl2MDP)-containing liposomes. No effect of liposome-entrapped Cl2MDP could be seen on nonphag …
WebDichloromethylene diphosphonate (MDPCl2) encapsulated in multilamellar liposomes was selectively incorporated by macrophages, immediately transferred to lysosomes, … insult definitionWebDichloromethylene diphosphonate (Cl 2 MDP) is a synthetic compound related in structure to inorganic pyrophosphate but is resistant to enzymatic and chemical … jobs for information technology majorsWebSigma-Aldrich. 233183. Clodronate, Disodium Salt - CAS 88416-50-6 - Calbiochem. A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. insultech block oldcastleWebDichloromethylene diphosphonate (clodronate), a new compound, has powerful activity against osteoclasts and has been used successfully to treat hypercalcemia associated with cancer. We studied... insultech chicagoWebJul 30, 2012 · A single intra-articular injection of liposomes encapsulating the drug dichloromethylene diphosphonate (CL 2 MDP) in the mouse knee joint caused selective elimination of synovial lining cells. Depletion of cells occurred within a few days as evidenced by light microscopic, electron microscopic and immunohistochemical studies. insultech group p/lWebDichloromethylene diphosphonate can be used for temporary elimination of macrophages in the spleen when administered after entrapment in liposomes. No comparable effect on … insultech blanket insulationWebNov 1, 1984 · Outre leur action remarquable dans la maladie osseuse de Paget, les diphosphonates sont très efficaces dans le traitement des hypercalcémies dont l'origine osseuse est presque toujours essentielle. Dans les hypercalcémies malignes, l'EHDP, le CL2 MDP et l'APD, les trois diphosphonates testés chez l'homme font chuter la calcémie … insultech ag