http://www.robholland.com/Nursing/Drug_Guide/data/monographframes/D003.html WebCladribine is a synthetic antineoplastic agent with selective toxicity toward certain normal and malignant lymphocytes and monocytes. It accumulates intracellularly, preventing repair of single-stranded DNA breaks and ultimately interfering with cellular metabolism and DNA synthesis. Therapeutic Effects
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WebAdult: Topical 0.05–0.4% solution in 30% alcohol to paint entire body (60 mLs) or ointment 1–2 times/d for 6–8 wk (10 mg/d) (must be specially compounded) Administration Note: When administering IV to infants and children, verify correct IV concentration and rate of infusion with physician. Intravenous Cell cycle-nonspecific, i.e., effective throughout the entire cell life cycle. Carcinogenicity has not been fully studied, but other compounds with similar action mechanisms and mutogenicity have been studied. See more History of hypersensitivity to cisplatin or other platinum-containing compounds; impaired renal function; myelosuppression; impaired hearing; history of gout and … See more A heavy metal complex with platinum as central atom surrounded by 2 chloride atoms and 2 ammonia molecules in the cis chemical position. Biochemical properties similar to those of bifunctional alkylating agents. Produces … See more Established combination therapy (cisplatin, vinblastine, bleomycin) in patient with metastatic testicular tumors and with doxorubicin for metastatic ovarian tumors following appropriate surgical or radiation therapy. See more hyperactive efx
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